Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes
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چکیده
منابع مشابه
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes.
Endoplasmic reticulum (ER) stress is a key link between obesity, insulin resistance, and type 2 diabetes. Here, we provide evidence that this mechanistic link can be exploited for therapeutic purposes with orally active chemical chaperones. 4-Phenyl butyric acid and taurine-conjugated ursodeoxycholic acid alleviated ER stress in cells and whole animals. Treatment of obese and diabetic mice with...
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ژورنال
عنوان ژورنال: Science
سال: 2006
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1128294